Bone Regulation - Cell Interactions to Disease
School of Computer Science and Software Engineering
Engineering Computational Biology
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    Bone Regulation - Cell Interactions to Disease

    Project Description
    Bone is a dynamic living tissue which has the ability to change its mass and structure in response to changes of the physiochemical and mechanical environment. Bone remodeling is the process of bone resorption by osteoclasts followed by bone formation by osteoblasts. This process is regulated by a finely tuned communication network between bone cells, cells of the bone environment and various regulatory factors. The project aim is to better understand this dynamic communication network which when disrupted leads to bone diseases. A synergistic approach linking mathematical modeling tightly together with experimental findings will give new insights into bone regulation.

    Many bone disorders such as osteoporosis, Paget's disease and cancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).

    Staff

    Publications

    • P. Pivonka, J. Zimak, D.W. Smith, B.S. Gardiner, C.R. Dunstan, N.A. Sims, T.J. Martin, G.R. Mundy. Model Structure and Control of Bone Multicellular Units: A Theoretical Study. BONE, 43(2), 249-263, 2008.
    • P. Pivonka, D. Smith, B. Gardiner, and C. Dunstan. Hierarchical model describing bone cell dynamics: application to bone remodeling. In CD-ROM Proceedings of the 15th International Conference on Mechanics in Medicine and Biology (ICMMB-15), pp 225-226, 2006.
    • P. Pivonka, D. Smith, B. Gardiner, C. Dunstan. Mathematical modeling of bone cell interactions: application to bone remodeling, 4th Clare Valley Bone Meeting, Clare Valley, South Australia, May 19-21, 2006. (poster + oral)
    • P. Pivonka, D. Smith, B. Gardiner, and C. Dunstan. Numerical investigation of bone cell remodeling by means of a cell population dynamics model. Engineering and Physical Science in Medicine (EPSM), Queensland, Australia,11-21 Sept., 2006. (oral)
    • P. Pivonka, D. Smith, B. Gardiner, and C. Dunstan., N. Sims, T.J. Martin, Mathematical model describing bone cell interactions: application to bone remodeling. ComBio 2006, Queensland, Australia, 24-28 Sept., 2006. (poster)
    • P. Pivonka, D. Smith, B. Gardiner, and C. Dunstan. Role of mathematical modeling in bone biology: from intracellular signaling to tissue level. 16th Annual Meeting of the Australian and New Zealand Bone and Mineral Society, Queensland, Australia, 23-26 Oct., 2006. (poster)
    • P. Pivonka, D. Smith, B. Gardiner, and C. Dunstan. Hierarchical model describing bone cell dynamics: application to bone remodeling. 15th International Conference on Mechanics in Medicine and Biology (ICMMB-15), Singapore, 6-8 Dec., 2006. (oral)
    • P. Pivonka, D.W. Smith, B.S. Gardiner, and C.R. Dunstan, Towards a mathematical description of bone remodeling, 2nd FEBS Advanced Lecture Course on Systems Biology, Gosau, Austria, 10-16 March, 2007.
    • D.W. Smith, P. Pivonka, B. S. Gardiner, C.R. Dunstan, T.J. Martin, State-of-the-art mathematical modelling approaches applied to bone biology, 17th Annual Meeting of the Australian and New Zealand Bone and Mineral Society, Queenstown, New Zealand, 9-12 September, 2007.
    • P. Pivonka, J. Zimak, D. Smith, B. Gardiner, C. Dunstan, N. Sims, T.J. Martin, How does RANKL/OPG receptor expression on osteoblasts modulate bone remodeling? . A theoretical study, ComBio 2007, Sydney, Australia, 22-26 September, 2007.
    • P. Pivonka, J. Zimak, D. Smith, B. Gardiner, C. Dunstan, N. Sims, T.J. Martin, Numerical study of the effects of PTH dosing type on bone balance, ANZORS-07, Australian and New Zealand Orthopaedic Research Society Meeting, Auckland, New Zealand, 14-17 October, 2007.
    • P. Pivonka and D.W Smith, Mathematical modelling of bone cell Interactions, Molecular signalling in bone remodelling, Inaugural Asia Pacific Conference 2007, Sydney, Australia, 23-25 Nov., 2007. (invited oral)
    • P. Pivonka, J. Zimak, D.W Smith, B.S. Gardiner, C.R. Dunstan, T.J. Martin, N.S. Sims, G.R. Mundy, Model Structure and control mechanisms for bone multi-cellular units: a theoretical study, Molecular Modeling - MM 2007, Melbourne, Australia, 27 . 30 Nov., 2007.

        Groovy biomedical image Activation-Resorption-Formation (ARF) sequence: bone tissue adaption by basic multicellular units (BMUs) executing bone remodelling.  

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Last updated: July 15 2015 09:16:54.