The central paradigm of skeletal mechanobiology is that mechanical forces modulate morphological and structural fitness of the skeletal tissues . bone, cartilage, ligament and tendon. The concept of bone remodeling by basic multicellular units (BMUs) is well established, but the mechanism by which osteoclasts and osteoblasts are activated in order to start resorption and formation of bone mass remains so far poorly understood. Extensive studies emphasize the role of osteocytes as being the mechanosensory cells of bone, and the lacuno-canalicular network as the structure that mediates mechanosensing. Strain-derived flow of interstitial fluid through this network appears to mechanically activate the osteocytes, as well as ensuring transport of cell signaling molecules, nutrients, and waste products. Finding the details of the specific mechanisms by which local bone gain and loss is mediated, is essential for the prognosis of osteosporosis, control of bone implants, and understanding of changes in microgravity (as occurs in space flights).
To better understand the mechano-signal transduction mechanism, this project aims to formulate a new state-of-the-art mathematical model that includes coupled electrochemical, chemomechanical, and electromechanical effects. It is believed that the numerical results will give new answers to the question how mechanotransduction and bone remodeling operates in tissue.