Chemo-mechanical Tissue Environment

Traditional engineering concepts, such as continuum mechanics and mass transport (advective-reactive-diffusion), are being used to help understand biological systems. For example, cells may respond to chemical and mechanical signals in their environment. Quantitative models are needed to integrate the various chemical and physical processes operating in a tissue. Biosyntheis and matrix degradation both may alter the mechanical, transport and chemical properties of the tissue. Hence multiple feedbacks systems occur within tissues and will govern processes from tumour growth, organism development to drug uptake. We are involved in a number of projects which range from fundamental questions in physiology to potential improvements in clinical treatment strategies. Projects within this research theme are outlined below.

Cartilage mechanics, nutrient transport & biosynthesis
Control of oxygen delivery to renal tissue by arterial-to-venous oxygen shunting
Bone mechanics & strain sensing
Wnt signaling and colorectal cancer
Fluid mechanics and wound healing after glaucoma surgery
Hydrocephalus hydrodynamics