A/Prof Bruce Gardiner
School of Computer Science and Software Engineering
Engineering Computational Biology
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    A/Prof Bruce Gardiner

    Engineering Computational Biology Group 
    Faculty of Engineering, Computing and Mathematics
    The University of Western Australia
    35 Stirling Highway, Crawley  WA 6009, Australia

    Email: bruce.gardiner@uwa.edu.au
    Phone: +61 8 6488 1537
    Fax: +61 8 6488 1089 
    Web: http://biomed.csse.uwa.edu.au

    Photo of Bruce

    Current Position:
    Associate Professor, Faculty of Engineering, Computing and Mathematics, The University of Western Australia

    Honorary Fellow, Department of Electrical and Electronic Engineering, The University of Melbourne, Australia

    Qualifications:
    Bachelor of Science (Physics 1st Class honours), 1994
    PhD (Chemical Engineering), 1999

    Research Interests:
    computational systems biology (modelling cell signalling networks),
    regenerative medicine and tissue engineering,
    biomedical engineering,
    developmental biology,
    integrative computational oncology,
    mathematical modelling with clinical applications

    cartilage, bone, tendon,
    cancer (colon, prostate, bone metastasis), kidneys, glaucoma
    cell response to physical and chemical microenvironment,
    mechanical and transport processes in biological tissues

    Grants:

    2014-2016
    ARC DP14010345 The comparative physiology of oxygen delivery to the kidney, D Smith, R Evans, B Gardiner, J Pearson, M Kett $505,000
    2013-2015
    NHMRC 1051538 Bridging the gap between cartilage biology and osteoarthritis risk prediction, B Gardiner, D Smith, D Lloyd, A Grodzinsky, L Zhang, T Besier $494,589
    2013-2015 NHMRC 1051455 Glycomic control of cartilage extra cellular matrix turnover, D Smith, D Coombe, B Gardiner, A Grodzinsky
    $682,895
    2012-2014 NHMRC 1029628 Investigating the roles of the wnt and notch signalling systems in colon, A Burgess, B Gardiner, D Smith $584,675
    2011-2014 ARC LP110100581 Bioengineered bioscaffolds for Achilles tendinopathy treatment, DG Lloyd, DW Smith, J Xu, BS Gardiner, TB Kirk, J Rubenson, M Zheng $840,000
    $500,000 (industry)
    2010-2012 NH&MRC 606601 Hypoxia is the common pathway to renal failure, R Evans, J Bertram, M Schlaich, B Gardiner D Smith, J Phillips $476,000
    2009 UWA Professor-at-large Scheme. Grant to have Professor Alan Grodzinsky (MIT) visit UWA twice during 2010-2011 $30,000
    2009-2011 ARC DP0988001 Engineering cartilage homeostasis in health and disease, DW Smith, BS Gardiner, AJ Grodzinsky $230,000
    2009-2011 NH&MRC 542531 Stimulations of colon cancer, AW Burgess, DW Smith, BS Gardiner $528,750
    2009-2011 NH&MRC 529918 Regulating fluid mechanics to improve the outcome of glaucoma surgery, JG Crowston, DW Smith, BS Gardiner, MA Coote $269,250
    2009-2010 Prostate Cancer Foundation of Australia Concept grant CG10 Integrative systems modelling of prostate cancer bone metastases, DW Smith, BS Gardiner, P Pivonka, GR Mundy, NA Bhowmick. $280,000
    2005 Australian Academy of Science Scientific visits to the United States, Canada and Mexico. Visit to Center for Biomedical Engineering, Massachusetts Institute of Technology, Boston USA. $8500
    2003 Melbourne Research Grant Scheme, A. Tordesillas, B. Gardiner $25,200
    2002 ARC Australian Postdoctoral Fellowship (APD) DP0211085 Behaviour of particles in flotation froths, G Jameson, AV Nguyen, JS Van Deventer, BS Gardiner -
    1995 University of Newcastle Postgraduate Research Scholarship $80,000

    Publications

    Google Scholar

    Book Chapter:

    Zhang, L.,  B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, The Transport of Insulin-like Growth Factor through Cartilage, in Porous Media Applications in Biological Systems and Biotechnology, Editor K. Vafai, CRC, 1st Edition, pg 399-453, Dec 2010.   pdf

    Journal Publications:

    2014

    Zhang, L., S. Miramini, D.W. Smith, B.S. Gardiner, A.J. Grodzinsky, Time evolution of deformation in a human cartilage under cyclic loading, Annals of Biomedical Engineering, 1-12, 2014.

    Shim,V.B., J.W. Fernandez, P.B. Gamage, C. Regnery, D.W. Smith, B.S. Gardiner, D.G. Lloyd, T.F. Besier, Subject-specific finite element analysis to characterize the influence of geometry and material properties in Achilles tendon Rupture, Journal of Biomechanics, 2014.

    J.P. Ngo, S. Kar, M.M. Kett, B.S. Gardiner, J.T. Pearson, D.W. Smith, J. Ludbrook, J.F. Bertram, R.G. Evans, Vascular geometry and oxygen diffusion in the vicinity of artery-vein pairs in the kidney, American Journal of Physiology-Renal Physiology, 2014. pdf

    C.W. Tan, B.S. Gardiner, Y. Hirokawa, D.W. Smith, A.W. Burgess, Analysis of Wnt signaling beta-catenin spatial dynamics in HEK293T cells, BMC Systems Biology 8 (1), 44, 2014. pdf

    Evans, R.G., J. Smith, C. Wright, B.S. Gardiner, D.W. Smith, A. Cochrane, Urinary oxygen tension: a clinical window on the health of the renal medulla?, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 306(1),R45-R50, 2014. pdf

    2013

    Tan, C.W., Y. Hirokawa, B.S. Gardiner, D.W. Smith, A.W. Burgess, Colon cryptogenesis: Asymmetric budding, PLoS ONE 8(10): e78519. doi:10.1371/journal.pone.0078519, 2013. pdf

    van der Wath, R.C., B.S. Gardiner, A.W. Burgess, D.W. Smith, Cell organisation in the colonic crypt: A theoretical comparison of the pedigree and niche concepts, PLoS ONE 8(9): e73204. doi:10.1371/journal.pone.0073204e66870, 2013. pdf

    Zhang, L., D.S. Smith, B.S. Gardiner, A.J. Grodzinsky, Modeling the Insulin-like Growth Factor system in articular cartilage, PLoS ONE 8(6), e66870, 2013. pdf

    Smith, D.W., J. Rubenson, D. Lloyd, M.H. Zheng, J. Fernandez, T. Besier, J. Xu, B.S. Gardiner, A conceptual framework for computational models of Achilles tendon homeostasis, WIREs Systems Biology and Medicine, 2013. doi: 10.1002/wsbm.1229. pdf

    Evans, R.G., C. Ince, J.A. Joles, D.W. Smith, C.N. May, P.M. O’Connor, B.S. Gardiner, Haemodynamic influences on kidney oxygenation: The clinical implications of integrative physiology, Clinical and Experimental Pharmacology and Physiology, 40(2): 106-122, 2013. pdf

    Smith, D.W., B.S. Gardiner, J. Davidson, A.J. Grodzinsky, Computational model for the analysis of cartilage and cartilage tissue constructs, Journal of Tissue Engineering and Regenerative Medicine, doi: 10.1002/term.1751, 2013. pdf

    Wang, T., Z. Lin, R.E. Day, B.S. Gardiner, E. Landao-Bassonga, J. Rubenson, T.B. Kirk, D.W. Smith, D.G. Lloyd, G. Hardisty, A. Wang, M.H. Zheng, Programmable mechanical stimulation on tendon homeostasis in a bioreactor system, Biotechnology and Bioengineering, 110(5): 1495-1507, 2013. pdf

    2012

    Wang, T., Gardiner, B.S., Lin, Z., Rubenson, J., Kirk, T.B., Wang, A., Xu, J., Smith, D.W., Lloyd, D.G., Zheng, M.H., Bioreactor design for tendon/ligament engineering, Tissue Engineering 19(2): 1-14, 2012 pdf

    Nguyen, D.Q., Ross, C.M., Li, Y.Q., Lo, I., Pandav, S., Gardiner, B., Smith, D., How, A.C., Crowston, J.G., Coote, M.A., A model to measure fluid outflow in rabbit capsules post glaucoma implant surgery, IOVS- Investigative Ophthalmology & Visual Science 53: 6914-6919, 2012.  pdf

    Gardiner, B.S., Thompson, S.L., Ngo, J.P., Smith, D.W., Abdelkader, A., Broughton, B.R.S., Bertram, J.F., Evans, R.G., Diffusive oxygen shunting between vessels in the pre-glomerular renal vasculature: anatomical observations and computational modeling, American Journal of Physiology - Renal Physiology 303: F605-F618, 2012, doi:10.1152/ajprenal.00186.2012  pdf

    Smith, D.W., Gardiner, B.S., Dunstan, C., Bone balance within a cortical BMU: local controls of bone resorption and formation, PLoS ONE 7(7): e40268, 2012. doi:10.1371/journal.pone.0040268.  pdf

    Buenzli, P.R., Pivonka, P., Gardiner, B.S., Smith, D.W., Modelling the anabolic response of bone using a cell population model, Journal of Theoretical Biology 307: 42-52, 2012  pdf

    Tan, C.W., Gardiner, B.S., Hirokawa, Y., Layton, M.J., Smith, D.W., Burgess, A.W., Wnt signalling pathway parameters for mammalian cells, PLoS ONE 7(2): e31882, 2012. doi:10.1371/journal.pone.0031882.  pdf

    2011

    Gardiner, B.S., L. Zhang, D.W. Smith, P. Pivonka, A.J. Grodzinsky, A mathematical model for targeting chemicals to tissues by exploiting complex degradation, Biology Direct 6:46, 1-16, 2011.

    Gardiner, B.S., D.W. Smith, P.M. O'Connor, R.G. Evans, A mathematical model of diffusional shunting of oxygen from arteries to veins in the kidney, American Journal of Physiology - Renal Physiology 300: F1339-F1352, 2011.  pdf

    2010

    Gardiner, B.S.,  D.W. Smith, M. Coote, J.G. Crowston, Computational modeling of fluid flow and intra-ocular pressure following glaucoma surgery, PLoS ONE 5(10): e13178, 2010. doi:10.1371/journal.pone.0013178   pdf

    Zhang, L., Gardiner, B.S., Smith, D.W., Pivonka, P., Grodzinsky, A.J., On the role of diffusible binding partners in modulating the transport and concentration of proteins in tissues, Journal of Theoretical Biology 263: 20-29, 2010.  pdf

    Pivonka, P., J. Zimak, D.W. Smith, B.S. Gardiner, C.R. Dunstan, N.A. Sims, T.J. Martin, G.R. Mundy, Theoretical investigation of the role of the  RANK-RANKL-OPG system in bone remodeling, Journal of Theoretical Biology 262: 306:316, 2010. pdf

    2009

     

    Zhang, L.,  B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, Integrated model of IGF-I mediated biosynthesis in deformed articular cartilage, Appeared in a topically issue on Micro and Nanomechanics of Biological and Bio-inspired Materials, Journal of Engineering Mechanics 135(5): 439-449, 2009.  pdf

     

    Pivonka, P., G.A. Narsilio, R.N. Li, D.W. Smith, B. Gardiner, Electrodiffusive Transport in Charged Porous Media: From the Particle-Level Scale to the Macroscopic Scale Using Volume Averaging, Journal of Porous Media 12(2):101-118, 2009. pdf

    2008

     

    Zhang, L., B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, IGF Uptake with Competitive Binding in articular cartilage, Journal of Biological Systems 6(2):175-195, 2008. link

     

    Pivonka, P., J. Zimak, D.W. Smith, B. Gardiner, C.B. Dunstan, N.A. Sims, T.J. Martin, G. Mundy. Model structure and control of bone remodeling: A theoretical study, Bone 43: 249-263, 2008. link

     

    Zhang, L., B. Gardiner, D.W. Smith, P. Pivonka, A. Grodzinsky, A fully coupled poroelastic reactive-transport model of cartilage, Molecular & Cellular Biomechanics 5(2): 133-153, 2008. link

    Evans, R.G., B.S Gardiner, D.W. Smith, P.M. O'Connor, Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis, American Journal of Physiology - Renal Physiology 295: F1259-F1270, 2008. pdf

    Evans, R.G., B.S Gardiner, D.W. Smith, P.M. O'Connor, Methods for studying the physiology of kidney oxygenation, Clinical and Experimental Pharmacology and Physiology 35: 1405-1412, 2008. pdf

    2007

     

    Zhang, L., B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, The effect of cyclic deformation and solute binding on solute transport in cartilage, Archives of Biochemistry and Biophysics 457 : 47-56, 2007. pdf

     

    Gardiner, B.S., D.W. Smith, P. Pivonka, A.J. Grodzinsky, E.H. Frank and L. Zhang, Solute transport in cartilage undergoing cyclic deformation, Computer Methods in Biomechanics and Biomedical Engineering 10: 265-278, 2007. link

     

    Pivonka, P., Smith, D.W., B. Gardiner, Investigation of Donnan equilibrium in charged porous materials . a scale transition analysis, Transport in Porous Media 69 : 215-237, 2007.   pdf

     

    <2006

    Gardiner B.S., A. Tordesillas. Effects of particle size distribution in a three-dimensional micropolar continuum model of granular media, Powder Technology 161: 110-121, 2006. pdf

     

     

    Gardiner, B.S., D.W. Smith, P. Pivonka. A two-dimensional mathematical model for dorsal appendage cell patterning in Drosophila. Developmental Biology 283: 688, 553, 2005.

     

    Boudreau, B.P., C. Algar, B.D. Johnson, I. Croudace, A. Reed, Y. Furukawa, K.M. Dorgan, P.A. Jumars, A.S. Grader, B.S. Gardiner. Bubble growth and rise in soft sediments, Geology 33(6): 517-520, 2005.

     

    Gardiner B.S., A. Tordesillas, The link between discrete and continuous modeling of liquid foam at the level of a single bubble. Journal of Rheology 49(4): 819-838, 2005.

     

    Gardiner B.S., A. Tordesillas, Micromechanical constitutive modelling of granular media: evolution and loss of contact in particle clusters, Journal of Engineering Mathematics 52 (1-3): 93-106, 2005.

     

    Tordesillas, A., S. D. C. Walsh, B.S. Gardiner, Bridging the length scales: micromechanics of granular media. BIT Numerical Mathematics 44: 539-556, 2004.

     

    Gardiner, B.S., A. Tordesillas, Micromechanics of shear bands. International Journal of Solids and Structures 41, pp. 5885-5901, 2004.

     

    Tordesillas, A., J.F. Peters, B.S. Gardiner, Shear band evolution and accumulated microstructural development in Cosserat media. International Journal of Numerical and Analytical Methods in Geomechanics. 28: pp. 981-1010, 2004.

     

    Tordesillas, A., J. F. Peters, B.S. Gardiner, Insights into 1D localisation theory and micromechanical constitutive laws. Geotechnique. 54: 327-330, 2004.

     

    Gardiner, B.S., B. P. Boudreau, B. D. Johnson, Slow growth of an isolated disk-shaped bubble of constant eccentricity in the presence of a distributed gas source. Applied Mathematical Modelling 27: 817-829, 2003.

     

    Gardiner, B.S., B. P. Boudreau B. D. Johnson, Growth of disk-shaped bubbles in sediments. Geochimica et Cosmochimica Acta 67: 1485-1494, 2003.

     

    Johnson, B.D., B. P. Boudreau, B.S. Gardiner, R. Maas, Mechanical response of sediments to bubble growth. Marine Geology 187: 347-363, 2002.

     

    Boudreau, B.P., B.S. Gardiner, B. D. Johnson, Rate of growth of isolated bubbles in sediments with a diagenetic source of methane (vol 46, pg 616, 2001). Limnology and Oceanography. 46: 1578-1578, 2001.

     

    Boudreau, B.P., B.S. Gardiner, B. D. Johnson, Rate of growth of isolated bubbles in sediments with a diagenetic source of methane, Limnology and Oceanography 46: 616-622, 2001.

     

    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson. Coarsening of two- and three-dimensional wet polydisperse foams. Philosophical Magazine A-Physics of Condensed Matter Struct. Defects Mech. Prop. 80: 981-1000, 2000.

     

    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, The steady shear of three-dimensional wet polydisperse foams. Journal of Non-Newtonian Fluid Mechanics 92: 151-166, 2000.


    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, The evolution of defects in a two-dimensional wet foam. Journal of Physics-Condensed Matter 11: 5437-5453, 1999.

     

    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, Prediction of pressure losses in pipe flow of aqueous foam. Industrial and Engineering Chemistry Research 38: 1099-1106, 1999.

     

    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, Rheology of fire-fighting foams. Fire Safety Journal 31: 61-75, 1998.

     

    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, R. P. Chhabra. Yield stress measurements of aqueous foams in the dry limit. Journal of Rheology 42: 1437-1450, 1998.



    Peer-reviewed conference proceedings:

    Smith, D.W., L. Zhang, B.S. Gardiner, P. Pivonka, A.J. Grodzinsky, Effects of ECM binding on solute transport in cyclically deformed cartilage, The 53rd Annual Meeting of the Orthopaedic Research Society, San Diego USA, 11-14th February, 2007, Paper No. 0101.

    Zhang, L., B.S. Gardiner, D.W. Smith, P. Pivonka, Solute Transport in Cartilage: Effects of Cyclic Deformation and ECM Binding, 15th International Conference on Mechanics in Medicine and Biology (ICMMB-15), Singapore, 6-8th December, pp 171-172, 2006.

    Pivonka, P., D. Smith, B. Gardiner and C. Dunstan. Hierarchical model describing bone cell dynamics: application to bone remodeling. 15th International Conference on Mechanics in Medicine and Biology (ICMMB-15), Singapore, 6-8 December, pp 225-226, 2006.

    Pivonka, P., Smith, D.W., B. Gardiner, Fundamental theoretical study of nanoscale ion transport through charged porous materials: Part I . diffusion. In Y. Abousleiman, A. Cheng, F.-J. Ulm, editors, Proceedings of the 3rd Biot Conference on Poromechanics (Oklahoma City, USA, May 24-27, 2005), A.A. Balkema Publishers, London, UK, pp 417-422, 2005.

    Pivonka, P., Smith, D.W., B. Gardiner, Fundamental theoretical study of nanoscale ion transport through charged porous materials: Part II ‚¬ diffusion-advection. In Y. Abousleiman, A. Cheng, F.-J. Ulm, editors, Proceedings of the 3rd Biot Conference on Poromechanis (Oklahoma City, USA, May 24-27, 2005), A.A. Balkema Publishers, London, UK, pp 449-453, 2005.

    Pivonka, P., D. Smith, B. Gardiner, Modeling of Donnan Equilibrium in charged porous materials . a scale transition analysis, In D.R.J. Owen and E. Oƒ± and B. Suƒ¡z, editors, Proceedings of the 8th International Conference on Computational Plasticity (COMPLAS VIII, Barcelona, Spain, 5-8 September, 2005), pp 147-151, 2005.

    Pivonka, P., D. Smith, B. Gardiner, Upscaling of the Poisson-Nernst-Planck Equations using the Volume Averaging Method, In T.E. Simos, and G. Psihoyios, and Ch. Tsitouras, editors, Proceedings of International Conference on Numerical Analysis and Applied Mathematics 2005 (ICNAAM, Rhodes, Greece, 16-20 September, 2005), pp 443-446, 2005, Wiley-VCH.

    Gardiner, B.S., Smith, D.W., Pivonka, P., Grodzinsky, A.J. Transport of large molecules through articular cartilage subject to dynamic loading' 10th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society, Sydney, Australia, 22-24 October, 2004.

    Gardiner, B.S., A. Tordesillas, Evolution of anisotropies in shear bands. Proceedings of the Workshop Quasi-Static Deformations of Particulate Materials (QuaDPM'03), Budapest, Hungary, pp 107-118, 2003.

    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson. Yield-stress measurements of fire-fighting foams. Halon Technical Working Conference, Albuquerque, USA, 1998.

    Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, Prediction of pressure losses in pumping of compressed-air fire-fighting foams. 5th International Symposium on Fire Safety Science, Melbourne, Australia, 1997.

    Gardiner, B.S., B. Z. Dlugogorski, G. J. Jameson, Behaviour of foams in tubular flow. Proceedings of 2nd Pacific Rim Conference on Rheology, Melbourne, Australia, 1997.

    Gardiner, B.S., B. Z. Dlugogorski, G. J. Jameson, Molecular dynamic simulation of static and shear flow behaviour of wet foams. CHEMECA .97, Rotorua, New Zealand, 1997.

    Gardiner, B.S., B. Z. Dlugogorski, G. J. Jameson, Flow and rheology of high-expansion foams in pipes. Proceedings of the XIIth International Congress of Rheology, Quebec, Canada, 1996

    Gardiner, B.S., Hu, Y.D., B.J. Fraser, Kelvin-Helmholtz instability within magnetotail boundary layers, paper GAB41I-4, XXI General Assembly of the International Union of Geodesy and Geophysics, Boulder USA, July 1995.

    Technical report:

    Gardiner, B.S., A. Tordesillas, Incorporating combined micro-slip and gross-slip at inter-particle contacts in the development of constitutive laws for granular media, US ARO Technical Report Grant No DAAD19-02-1-0216, Dec 2001.

    PhD Students Supervised
    Lihai Zhang, completed 2008.
    Chin Wee Tan, completed 2011.
    Tao Wang, completed 2014.

    Teaching Experience

    421-699 Fields, Forces and Flows in Biological Systems (Melbourne U.).
    421-692 Biological Systems Engineering (Melbourne U.).
    421-285 Bioengineering systems modelling 1 and 2 (Melbourne U.)

    CITS2401 Computational Analysis and Visualisation (UWA)
    ENSC3005 Mass and Energy Balance (UWA)
    CHPR4407 Transport Phenomena (UWA)

     

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School of Computer Science & Software Engineering
Faculty of Engineering, Computing & Mathematics
The University of Western Australia
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Last updated: November 13 2014 14:56:24.