A/Prof Bruce Gardiner

Engineering Computational Biology Group  School of Computer Science and Software Engineering The University of Western Australia 35 Stirling Highway, Crawley  WA 6009, Australia Email: bruce.gardiner@uwa.edu.au Phone: +61 8 6488 1537 Fax: +61 8 6488 1089  Web: http://biomed.csse.uwa.edu.au

Current Position:
Associate Professor, School of Computer Science and Software Engineering, The University of Western Australia

Honorary Fellow, Department of Electrical and Electronic Engineering, The University of Melbourne, Australia

Qualifications:
Bachelor of Science (Physics 1st Class honours), 1994
PhD (Chemical Engineering), 1999

Research Interests:
computational systems biology (modelling cell signalling networks),
developmental biology,
integrative computational oncology,
regenerative medicine and tissue engineering,
biomedical engineering,
mathematical modelling with clinical applications

cartilage, bone, tendon,
cancer (colon, prostate, bone metastasis), kidneys, glaucoma
cell response to physical and chemical microenvironment,
mechanical and transport processes in biological tissues

Grants:

2013-2015	NHMRC 1051538 Bridging the gap between cartilage biology and osteoarthritis risk prediction, B Gardiner, D Smith, D Lloyd, A Grodzinsky, L Zhang, T Besier	$494,589
2013-2015	NHMRC 1051455 Glycomic control of cartilage extra cellular matrix turnover, D Smith, D Coombe, B Gardiner, A Grodzinsky	$682,895
2012-2014	NHMRC 1029628 Investigating the roles of the wnt and notch signalling systems in colon, A Burgess, B Gardiner, D Smith	$584,675
2011-2014	ARC LP110100581 Bioengineered bioscaffolds for Achilles tendinopathy treatment, DG Lloyd, DW Smith, J Xu, BS Gardiner, TB Kirk, J Rubenson, M Zheng	$840,000 + $500,000 (industry)
2010-2012	NH&MRC 606601 Hypoxia is the common pathway to renal failure, R Evans, J Bertram, M Schlaich, B Gardiner D Smith, J Phillips	$476,000
2009	UWA Professor-at-large Scheme. Grant to have Professor Alan Grodzinsky (MIT) visit UWA twice during 2010-2011	$30,000
2009-2011	ARC DP0988001 Engineering cartilage homeostasis in health and disease, DW Smith, BS Gardiner, AJ Grodzinsky	$230,000
2009-2011	NH&MRC 542531 Stimulations of colon cancer, AW Burgess, DW Smith, BS Gardiner	$528,750
2009-2011	NH&MRC 529918 Regulating fluid mechanics to improve the outcome of glaucoma surgery, JG Crowston, DW Smith, BS Gardiner, MA Coote	$269,250
2009-2010	Prostate Cancer Foundation of Australia Concept grant CG10 Integrative systems modelling of prostate cancer bone metastases, DW Smith, BS Gardiner, P Pivonka, GR Mundy, NA Bhowmick.	$280,000
2005	Australian Academy of Science Scientific visits to the United States, Canada and Mexico. Visit to Center for Biomedical Engineering, Massachusetts Institute of Technology, Boston USA.	$8500
2003	Melbourne Research Grant Scheme, A. Tordesillas, B. Gardiner	$25,200
2002	ARC Australian Postdoctoral Fellowship (APD) DP0211085 Behaviour of particles in flotation froths, G Jameson, AV Nguyen, JS Van Deventer, BS Gardiner	-
1995	University of Newcastle Postgraduate Research Scholarship	$80,000

Students Supervised
Lihai Zhang, completed 2008.
Chin Wee Tan, completed 2011.
Tao Wang, (current)

Publications

Google Scholar

Book Chapter:

Zhang, L.,  B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, The Transport of Insulin-like Growth Factor through Cartilage, in Porous Media Applications in Biological Systems and Biotechnology, Editor K. Vafai, CRC, 1^st Edition, pg 399-453, Dec 2010.   pdf

Journal Publications:

2013

Evans, R.G., C. Ince, J.A. Joles, D.W. Smith, C.N. May, P.M. O’Connor, B.S. Gardiner, Haemodynamic influences on kidney oxygenation: The clinical implications of integrative physiology, Clinical and Experimental Pharmacology and Physiology, 40(2): 106-122, 2013. pdf

Smith, D.W., B.S. Gardiner, J. Davidson, A.J. Grodzinsky, Computational model for the analysis of cartilage and cartilage tissue constructs, Journal of Tissue Engineering and Regenerative Medicine, Accepted 19th March 2013.

Wang, T., Z. Lin, R.E. Day, B.S. Gardiner, E. Landao-Bassonga, J. Rubenson, T.B. Kirk, D.W. Smith, D.G. Lloyd, G. Hardisty, A. Wang, M.H. Zheng, Programmable mechanical stimulation on tendon homeostasis in a bioreactor system, Biotechnology and Bioengineering, Accepted 7/12/2012. pdf

2012

Wang, T., Gardiner, B.S., Lin, Z., Rubenson, J., Kirk, T.B., Wang, A., Xu, J., Smith, D.W., Lloyd, D.G., Zheng, M.H., Bioreactor design for tendon/ligament engineering, Tissue Engineering 19(2): 1-14, 2012 pdf

Nguyen, D.Q., Ross, C.M., Li, Y.Q., Lo, I., Pandav, S., Gardiner, B., Smith, D., How, A.C., Crowston, J.G., Coote, M.A., A model to measure fluid outflow in rabbit capsules post glaucoma implant surgery, IOVS- Investigative Ophthalmology & Visual Science 53: 6914-6919, 2012.  pdf

Gardiner, B.S., Thompson, S.L., Ngo, J.P., Smith, D.W., Abdelkader, A., Broughton, B.R.S., Bertram, J.F., Evans, R.G., Diffusive oxygen shunting between vessels in the pre-glomerular renal vasculature: anatomical observations and computational modeling, American Journal of Physiology - Renal Physiology 303: F605-F618, 2012, doi:10.1152/ajprenal.00186.2012  pdf

Smith, D.W., Gardiner, B.S., Dunstan, C., Bone balance within a cortical BMU: local controls of bone resorption and formation, PLoS ONE 7(7): e40268, 2012. doi:10.1371/journal.pone.0040268.  pdf

Buenzli, P.R., Pivonka, P., Gardiner, B.S., Smith, D.W., Modelling the anabolic response of bone using a cell population model, Journal of Theoretical Biology 307: 42-52, 2012  pdf

Tan, C.W., Gardiner, B.S., Hirokawa, Y., Layton, M.J., Smith, D.W., Burgess, A.W., Wnt signalling pathway parameters for mammalian cells, PLoS ONE 7(2): e31882, 2012. doi:10.1371/journal.pone.0031882.  pdf

2011

Gardiner, B.S., L. Zhang, D.W. Smith, P. Pivonka, A.J. Grodzinsky, A mathematical model for targeting chemicals to tissues by exploiting complex degradation, Biology Direct 6:46, 1-16, 2011.

Gardiner, B.S., D.W. Smith, P.M. O'Connor, R.G. Evans, A mathematical model of diffusional shunting of oxygen from arteries to veins in the kidney, American Journal of Physiology - Renal Physiology 300: F1339-F1352, 2011.  pdf

2010

Gardiner, B.S.,  D.W. Smith, M. Coote, J.G. Crowston, Computational modeling of fluid flow and intra-ocular pressure following glaucoma surgery, PLoS ONE 5(10): e13178, 2010. doi:10.1371/journal.pone.0013178   pdf

Zhang, L., Gardiner, B.S., Smith, D.W., Pivonka, P., Grodzinsky, A.J., On the role of diffusible binding partners in modulating the transport and concentration of proteins in tissues, Journal of Theoretical Biology 263: 20-29, 2010.  pdf

Pivonka, P., J. Zimak, D.W. Smith, B.S. Gardiner, C.R. Dunstan, N.A. Sims, T.J. Martin, G.R. Mundy, Theoretical investigation of the role of the  RANK-RANKL-OPG system in bone remodeling, Journal of Theoretical Biology 262: 306:316, 2010. pdf

2009

 

Zhang, L.,  B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, Integrated model of IGF-I mediated biosynthesis in deformed articular cartilage, Appeared in a topically issue on Micro and Nanomechanics of Biological and Bio-inspired Materials, Journal of Engineering Mechanics 135(5): 439-449, 2009.  pdf

 

Pivonka, P., G.A. Narsilio, R.N. Li, D.W. Smith, B. Gardiner, Electrodiffusive Transport in Charged Porous Media: From the Particle-Level Scale to the Macroscopic Scale Using Volume Averaging, Journal of Porous Media 12(2):101-118, 2009. pdf

2008

 

Zhang, L., B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, IGF Uptake with Competitive Binding in articular cartilage, Journal of Biological Systems 6(2):175-195, 2008. link

 

Pivonka, P., J. Zimak, D.W. Smith, B. Gardiner, C.B. Dunstan, N.A. Sims, T.J. Martin, G. Mundy. Model structure and control of bone remodeling: A theoretical study, Bone 43: 249-263, 2008. link

 

Zhang, L., B. Gardiner, D.W. Smith, P. Pivonka, A. Grodzinsky, A fully coupled poroelastic reactive-transport model of cartilage, Molecular & Cellular Biomechanics 5(2): 133-153, 2008. link

Evans, R.G., B.S Gardiner, D.W. Smith, P.M. O'Connor, Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis, American Journal of Physiology - Renal Physiology 295: F1259-F1270, 2008. pdf

Evans, R.G., B.S Gardiner, D.W. Smith, P.M. O'Connor, Methods for studying the physiology of kidney oxygenation, Clinical and Experimental Pharmacology and Physiology 35: 1405-1412, 2008. pdf

2007

 

Zhang, L., B.S. Gardiner, D.W. Smith, P. Pivonka, A.J. Grodzinsky, The effect of cyclic deformation and solute binding on solute transport in cartilage, Archives of Biochemistry and Biophysics 457 : 47-56, 2007. pdf

 

Gardiner, B.S., D.W. Smith, P. Pivonka, A.J. Grodzinsky, E.H. Frank and L. Zhang, Solute transport in cartilage undergoing cyclic deformation, Computer Methods in Biomechanics and Biomedical Engineering 10: 265-278, 2007. link

 

Pivonka, P., Smith, D.W., B. Gardiner, Investigation of Donnan equilibrium in charged porous materials . a scale transition analysis, Transport in Porous Media 69 : 215-237, 2007.   pdf

 

<2006

Gardiner B.S., A. Tordesillas. Effects of particle size distribution in a three-dimensional micropolar continuum model of granular media, Powder Technology 161: 110-121, 2006. pdf

 

 

Gardiner, B.S., D.W. Smith, P. Pivonka. A two-dimensional mathematical model for dorsal appendage cell patterning in Drosophila. Developmental Biology 283: 688, 553, 2005.

 

Boudreau, B.P., C. Algar, B.D. Johnson, I. Croudace, A. Reed, Y. Furukawa, K.M. Dorgan, P.A. Jumars, A.S. Grader, B.S. Gardiner. Bubble growth and rise in soft sediments, Geology 33(6): 517-520, 2005.

 

Gardiner B.S., A. Tordesillas, The link between discrete and continuous modeling of liquid foam at the level of a single bubble. Journal of Rheology 49(4): 819-838, 2005.

 

Gardiner B.S., A. Tordesillas, Micromechanical constitutive modelling of granular media: evolution and loss of contact in particle clusters, Journal of Engineering Mathematics 52 (1-3): 93-106, 2005.

 

Tordesillas, A., S. D. C. Walsh, B.S. Gardiner, Bridging the length scales: micromechanics of granular media. BIT Numerical Mathematics 44: 539-556, 2004.

 

Gardiner, B.S., A. Tordesillas, Micromechanics of shear bands. International Journal of Solids and Structures 41, pp. 5885-5901, 2004.

 

Tordesillas, A., J.F. Peters, B.S. Gardiner, Shear band evolution and accumulated microstructural development in Cosserat media. International Journal of Numerical and Analytical Methods in Geomechanics. 28: pp. 981-1010, 2004.

 

Tordesillas, A., J. F. Peters, B.S. Gardiner, Insights into 1D localisation theory and micromechanical constitutive laws. Geotechnique. 54: 327-330, 2004.

 

Gardiner, B.S., B. P. Boudreau, B. D. Johnson, Slow growth of an isolated disk-shaped bubble of constant eccentricity in the presence of a distributed gas source. Applied Mathematical Modelling 27: 817-829, 2003.

 

Gardiner, B.S., B. P. Boudreau B. D. Johnson, Growth of disk-shaped bubbles in sediments. Geochimica et Cosmochimica Acta 67: 1485-1494, 2003.

 

Johnson, B.D., B. P. Boudreau, B.S. Gardiner, R. Maas, Mechanical response of sediments to bubble growth. Marine Geology 187: 347-363, 2002.

 

Boudreau, B.P., B.S. Gardiner, B. D. Johnson, Rate of growth of isolated bubbles in sediments with a diagenetic source of methane (vol 46, pg 616, 2001). Limnology and Oceanography. 46: 1578-1578, 2001.

 

Boudreau, B.P., B.S. Gardiner, B. D. Johnson, Rate of growth of isolated bubbles in sediments with a diagenetic source of methane, Limnology and Oceanography 46: 616-622, 2001.

 

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson. Coarsening of two- and three-dimensional wet polydisperse foams. Philosophical Magazine A-Physics of Condensed Matter Struct. Defects Mech. Prop. 80: 981-1000, 2000.

 

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, The steady shear of three-dimensional wet polydisperse foams. Journal of Non-Newtonian Fluid Mechanics 92: 151-166, 2000.

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, The evolution of defects in a two-dimensional wet foam. Journal of Physics-Condensed Matter 11: 5437-5453, 1999.

 

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, Prediction of pressure losses in pipe flow of aqueous foam. Industrial and Engineering Chemistry Research 38: 1099-1106, 1999.

 

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, Rheology of fire-fighting foams. Fire Safety Journal 31: 61-75, 1998.

 

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, R. P. Chhabra. Yield stress measurements of aqueous foams in the dry limit. Journal of Rheology 42: 1437-1450, 1998.

Peer-reviewed conference proceedings:

Smith, D.W., L. Zhang, B.S. Gardiner, P. Pivonka, A.J. Grodzinsky, Effects of ECM binding on solute transport in cyclically deformed cartilage, The 53rd Annual Meeting of the Orthopaedic Research Society, San Diego USA, 11-14th February, 2007, Paper No. 0101.

Zhang, L., B.S. Gardiner, D.W. Smith, P. Pivonka, Solute Transport in Cartilage: Effects of Cyclic Deformation and ECM Binding, 15th International Conference on Mechanics in Medicine and Biology (ICMMB-15), Singapore, 6-8th December, pp 171-172, 2006.

Pivonka, P., D. Smith, B. Gardiner and C. Dunstan. Hierarchical model describing bone cell dynamics: application to bone remodeling. 15th International Conference on Mechanics in Medicine and Biology (ICMMB-15), Singapore, 6-8 December, pp 225-226, 2006.

Pivonka, P., Smith, D.W., B. Gardiner, Fundamental theoretical study of nanoscale ion transport through charged porous materials: Part I . diffusion. In Y. Abousleiman, A. Cheng, F.-J. Ulm, editors, Proceedings of the 3rd Biot Conference on Poromechanics (Oklahoma City, USA, May 24-27, 2005), A.A. Balkema Publishers, London, UK, pp 417-422, 2005.

Pivonka, P., Smith, D.W., B. Gardiner, Fundamental theoretical study of nanoscale ion transport through charged porous materials: Part II ¬ diffusion-advection. In Y. Abousleiman, A. Cheng, F.-J. Ulm, editors, Proceedings of the 3rd Biot Conference on Poromechanis (Oklahoma City, USA, May 24-27, 2005), A.A. Balkema Publishers, London, UK, pp 449-453, 2005.

Pivonka, P., D. Smith, B. Gardiner, Modeling of Donnan Equilibrium in charged porous materials . a scale transition analysis, In D.R.J. Owen and E. Oñ and B. Suáz, editors, Proceedings of the 8th International Conference on Computational Plasticity (COMPLAS VIII, Barcelona, Spain, 5-8 September, 2005), pp 147-151, 2005.

Pivonka, P., D. Smith, B. Gardiner, Upscaling of the Poisson-Nernst-Planck Equations using the Volume Averaging Method, In T.E. Simos, and G. Psihoyios, and Ch. Tsitouras, editors, Proceedings of International Conference on Numerical Analysis and Applied Mathematics 2005 (ICNAAM, Rhodes, Greece, 16-20 September, 2005), pp 443-446, 2005, Wiley-VCH.

Gardiner, B.S., Smith, D.W., Pivonka, P., Grodzinsky, A.J. Transport of large molecules through articular cartilage subject to dynamic loading' 10th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society, Sydney, Australia, 22-24 October, 2004.

Gardiner, B.S., A. Tordesillas, Evolution of anisotropies in shear bands. Proceedings of the Workshop Quasi-Static Deformations of Particulate Materials (QuaDPM'03), Budapest, Hungary, pp 107-118, 2003.

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson. Yield-stress measurements of fire-fighting foams. Halon Technical Working Conference, Albuquerque, USA, 1998.

Gardiner, B.S., B.Z. Dlugogorski, G.J. Jameson, Prediction of pressure losses in pumping of compressed-air fire-fighting foams. 5th International Symposium on Fire Safety Science, Melbourne, Australia, 1997.

Gardiner, B.S., B. Z. Dlugogorski, G. J. Jameson, Behaviour of foams in tubular flow. Proceedings of 2nd Pacific Rim Conference on Rheology, Melbourne, Australia, 1997.

Gardiner, B.S., B. Z. Dlugogorski, G. J. Jameson, Molecular dynamic simulation of static and shear flow behaviour of wet foams. CHEMECA .97, Rotorua, New Zealand, 1997.

Gardiner, B.S., B. Z. Dlugogorski, G. J. Jameson, Flow and rheology of high-expansion foams in pipes. Proceedings of the XIIth International Congress of Rheology, Quebec, Canada, 1996

Gardiner, B.S., Hu, Y.D., B.J. Fraser, Kelvin-Helmholtz instability within magnetotail boundary layers, paper GAB41I-4, XXI General Assembly of the International Union of Geodesy and Geophysics, Boulder USA, July 1995.

Technical report:

Gardiner, B.S., A. Tordesillas, Incorporating combined micro-slip and gross-slip at inter-particle contacts in the development of constitutive laws for granular media, US ARO Technical Report Grant No DAAD19-02-1-0216, Dec 2001.

Invited seminar and conference presentations

A short and long term look at cartilage homeostasis, Queensland University of Technology,
Institute of Health and Biomedical Innovation, 11th July 2011.

Engineering Computational Biology, Engineering and Physical Sciences in Medicine & The
Australian Biomedical Engineering Conference, Melbourne 5th-9th December 2010.
(Invited Keynote and Chair for sessions "Instrumentation and Bioengineering".

Fluid-tissue interactions following glaucoma surgery, Special Session on Mathematical Biology at 53^rd Annual Meeting of the Australian Mathematical Society, University of Adelaide, 28^th September-1^st October 2009.

Computational modelling of kidney oxygen regulation: counter-current flow and oxygen shunting, Department of Civil and Environmental Engineering, The University of Melbourne, 4^th September 2008.

Computational modelling of tissue homeostasis and injury, Department of Mathematics and Statistics, The University of Melbourne, 7^th of April 2008.

Computational Biology, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane (November, 2007)

How to build a mutant fly. Melbourne University Mathematics & Statistics Society, The University of Melbourne, 13^th of October 2006.

Metabolic Modelling. 8^th Melbourne Bioinformatics Course, Melbourne, 4-8^th September 2006.

Mathematical modelling of intercellular signalling in development and disease. Peter MacCallum Cancer Centre, Melbourne, Australia, 29^th of June, 2006.

Can cyclic loading enhance the transport of nutrients into cartilage? Department of Bioengineering, Massachusetts Institute of Technology, Cambridge, USA, 5^th of August 2005.

Network modelling and b-catenin, The Wnt signalling workshop, Ludwig Cancer Institute, Melbourne, Australia, 16^th of December, 2005.

The role and roll of particles in granular materials, The University of Newcastle, Newcastle, 2003.

What can a micromechanical model of granular materials do for you? Particulate Fluids Processing Centre Seminar Series, The University of Melbourne, 2003.

A new theory of evolution? Interface and Continuum Mechanics Seminar Series, Department of Mathematics and Statistics, The University of Melbourne, 2003.

Growing bubbles in marine sediments and gelatine, Interface and Continuum Mechanics Seminar Series, Department of Mathematics and Statistics, University of Melbourne, 2001.

Growing bubbles in foam, mud and gelatin, Sandia National Laboratories, Albuquerque, USA, 2001.

Rheology of aqueous foams, Unilever Colworth Research Laboratory, 1997.